Title : The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils.

Pub. Date : 1998 Jul

PMID : 9632805






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The cytoplasmic protein tyrosine kinase Syk has two amino-terminal SH2 domains that engage phosphorylated immunoreceptor tyrosine-based activation motifs in the signaling subunits of immunoreceptors. Tyrosine spleen tyrosine kinase Mus musculus
2 The tyrosine phosphorylation of multiple cellular polypeptides, including the FcgammaR gamma chain, as well as Erk2 activation, was compromised in Syk-/- macrophages after FcgammaR stimulation. Tyrosine spleen tyrosine kinase Mus musculus