| Protein Name | spleen tyrosine kinase |
|---|---|
| Organism | Mus musculus |
| Gene ID | 20963 |
| Gene Symbol | Syk |
| UniProt | P48025 (KSYK_MOUSE), Q3UPF7 (Q3UPF7_MOUSE), Q6P1E0 (Q6P1E0_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
210
Total Number of Articles : 294 |
Description |
spleen tyrosine kinase |
| Gene Summary |
Enables several functions, including ATP binding activity; SH2 domain binding activity; and enzyme binding activity. Involved in several processes, including cell surface receptor signaling pathway; myeloid cell activation involved in immune response; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including positive regulation of lymphocyte activation; positive regulation of macromolecule metabolic process; and protein phosphorylation. Located in early phagosome. Part of B cell receptor complex. Is expressed in liver and notochord. Human ortholog(s) of this gene implicated in immunodeficiency 82. Orthologous to human SYK (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |