Title : Mechanisms of hepatic transport of cyclosporin A: an explanation for its cholestatic action?

Pub. Date : 1997 Jul-Aug

PMID : 9626758






2 Functional Relationships(s)
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1 The photoaffinity labeling as well as CyA transport by canalicular membrane vesicles were inhibited by CyA and the p-glycoprotein substrates daunomycin and PSC-833, but not by taurocholate, indicating that CyA is excreted by p-glycoprotein. Daunorubicin ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
2 The photoaffinity labeling as well as CyA transport by canalicular membrane vesicles were inhibited by CyA and the p-glycoprotein substrates daunomycin and PSC-833, but not by taurocholate, indicating that CyA is excreted by p-glycoprotein. Daunorubicin ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus