Title : Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.

Pub. Date : 1998 Jun 19

PMID : 9624185






1 Functional Relationships(s)
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1 By 2 months of age, production of reactive oxygen species, determined by the peroxidation-sensitive fluorescent dye, 2",7"-dichlorofluorescin diacetate, was significantly elevated in TGF-alpha/c-myc transgenic hepatocytes versus either wild type or c-myc single transgenic cells, and occurred in parallel with an increase in lipid peroxidation. diacetyldichlorofluorescein transforming growth factor alpha Mus musculus