Pub. Date : 1998 Jun 19
PMID : 9624136
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ceramide activates NFkappaB by inducing the processing of p105. | Ceramides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Ceramide activates NFkappaB by inducing the processing of p105. | Ceramides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | In this paper, we directly compare the effects of the cell-permeable ceramide analogue, N-acetylsphingosine (C2-ceramide), with TNF, on NFkappaB function, a transcription factor whose activation is central to many TNF-mediated effects. | Ceramides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | However, electrophoretic mobility shift analysis following cell stimulation with this ceramide analogue revealed a dose-responsive activation of NFkappaB, which was not apparent following cell treatment with the inactive dihydro form. | Ceramides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Our data therefore suggest that ceramide promotes the activation of NFkappaB complexes that lack transactivating activity by enhanced processing of p105. | Ceramides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | Our data therefore suggest that ceramide promotes the activation of NFkappaB complexes that lack transactivating activity by enhanced processing of p105. | Ceramides | nuclear factor kappa B subunit 1 | Homo sapiens |