Title : Response of the hypothalamo-pituitary-adrenal axis to nicotine.

Pub. Date : 1998 Feb

PMID : 9621392

3 Functional Relationships(s)
Compound Name
Protein Name
1 Nicotine has been shown to be a potent stimulus for the secretion of the stress-responsive hormones, adrenocorticotropin (ACTH) and prolactin. Nicotine proopiomelanocortin Homo sapiens
2 Data are presented demonstrating that nicotine acts via a central mechanism to stimulate indirectly the release of ACTH from the anterior pituitary corticotropes. Nicotine proopiomelanocortin Homo sapiens
3 A reduction in the modulatory effect of these catecholamines (by neurotoxic lesion, synthetic enzyme inhibitors or adrenergic receptor antagonists) resulted in an inhibition of nicotine-stimulated ACTH secretion. Nicotine proopiomelanocortin Homo sapiens