Title : Insulin-like growth factor-I and -II in human benign prostatic hyperplasia: relationship with binding proteins 2 and 3 and androgens.

Pub. Date : 1998 May-Jun

PMID : 9618803






3 Functional Relationships(s)
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1 IGF-II was positively correlated with DHT (r = 0.78; p = 0.003) and 3 alpha diol (r = 0.66; p = 0.021) but not with IGFBPs. Dihydrotestosterone insulin like growth factor 2 Homo sapiens
2 These data suggest that in BPH, DHT modulates the IGF system by increasing IGF-II without modifying IGFBPs. Dihydrotestosterone insulin like growth factor 2 Homo sapiens
3 Therefore, the stroma-epithelium interaction, which plays an important role in prostatic growth, may be regulated by DHT through IGF-II. Dihydrotestosterone insulin like growth factor 2 Homo sapiens