Title : Genotyping of the arylamine N-acetyltransferase polymorphism in the prediction of idiosyncratic reactions to trimethoprim-sulfamethoxazole in infants.

Pub. Date : 1998 Jun

PMID : 9618736






3 Functional Relationships(s)
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1 The aim of the study was to compare the usefulness of the acetylation phenotype and NAT2 coding genotype in the prediction of idiosyncratic reaction to Cotrimoxazole in infants. Trimethoprim, Sulfamethoxazole Drug Combination N-acetyltransferase 2 Homo sapiens
2 However, it has been demonstrated that the risk of adverse effects of Cotrimoxazole is considerably higher in children with mutations of the NAT2 encoding gene. Trimethoprim, Sulfamethoxazole Drug Combination N-acetyltransferase 2 Homo sapiens
3 The comparison of the results from PCR-RFLP genotyping with phenotyping suggested that in infants, the NAT2 genotype rather than phenotype provides the basis for the detection of hypersensitivity to TMP-SMX. Trimethoprim, Sulfamethoxazole Drug Combination N-acetyltransferase 2 Homo sapiens