Protein Name N-acetyltransferase 2
Organism Homo sapiens
Gene ID 10
Gene Symbol

NAT2

UniProt P11245 (ARY2_HUMAN), A4Z6T7 (A4Z6T7_HUMAN)
Relationships Total Number of functionally related compound(s) : 326
Total Number of Articles : 534
Description

N-acetyltransferase 2

Gene Summary

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2). [provided by RefSeq, Sep 2019]

synonyms
  • arylamine N-acetyltransferase 2
  • N-acetyltransferase 2 (arylamine N-acetyltransferase)
  • N-acetyltransferase type 2
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Properties