Pub. Date : 1998 Apr
PMID : 9617571
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PGE2 inhibits IL-2 and IL-4-dependent proliferation of CTLL-2 and HT2 cells. | Dinoprostone | interleukin 2 | Mus musculus |
| 2 | Here we have used CTLL-2 and HT2 cells to investigate the effect of the inflammatory mediator prostaglandin E2 (PGE2) on IL-2- and IL-4-dependent proliferation. | Dinoprostone | interleukin 2 | Mus musculus |
| 3 | Here we have used CTLL-2 and HT2 cells to investigate the effect of the inflammatory mediator prostaglandin E2 (PGE2) on IL-2- and IL-4-dependent proliferation. | Dinoprostone | interleukin 2 | Mus musculus |
| 4 | PGE2 inhibited IL-2- as well as IL-4-dependent proliferation of both CTLL-2 and HT2 cells, with IL-4-dependent proliferation being more sensitive than IL-2-dependent proliferation and CTLL-2 cells being more sensitive than HT2 cells. | Dinoprostone | interleukin 2 | Mus musculus |
| 5 | The data suggest that even in cases where synthesis of IL-2 and IL-4 is differentially affected by PGE2, IL-2- and IL-4-dependent T cells may still be similarly sensitive to PGE2 by way of their cytokine responsiveness. | Dinoprostone | interleukin 2 | Mus musculus |
| 6 | PGE2 levels are an important consideration when CTLL-2 and HT2 cells are used for the measurement of IL-4 and IL-2. | Dinoprostone | interleukin 2 | Mus musculus |