Title : Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937).

Pub. Date : 1998 May

PMID : 9615391






1 Functional Relationships(s)
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1 Co-administration of bryostatin 1 with PMA antagonized the latter"s differentiation-inducing capacity and anti-proliferative effects, actions that were accompanied by a reduction in PMA-mediated p21CIP1/WAF1 induction, CDK2 inhibition, pRb dephosphorylation, and c-Myc downregulation. Tetradecanoylphorbol Acetate cyclin dependent kinase 2 Homo sapiens