Title : Progesterone can participate in down-regulation of the luteinizing hormone receptor gene expression and function in cultured murine Leydig cells.

Pub. Date : 1998 Feb

PMID : 9605514






2 Functional Relationships(s)
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1 Pre-incubation of the mLTC-1 cells for 48 h with P (1-10 micromol/l) decreased in dose-dependent fashion their specific binding of [125I]iodo-hCG as well as the hCG-induced cAMP production (down to 65 and 40% respectively, of controls, P < 0.01). Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
2 Similar effect of P on hCG-induced cAMP production was observed in adult mouse Leydig cells following a 24 h incubation in the presence of P (0.3-10 micromol/l). Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens