Title : Interruption of estradiol signal transduction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through disruption of the protein phosphorylation pathway in adipose tissues from immature and mature female rats.

Pub. Date : 1998 Apr 1

PMID : 9605431






3 Functional Relationships(s)
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Protein Name
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1 Doses of 2 and 10 microg TCDD/kg decreased adipose tissue epidermal growth factor receptor (EGFR) binding activity 5 and 7 days later in immature and mature females, respectively. Polychlorinated Dibenzodioxins epidermal growth factor receptor Rattus norvegicus
2 Doses of 2 and 10 microg TCDD/kg decreased adipose tissue epidermal growth factor receptor (EGFR) binding activity 5 and 7 days later in immature and mature females, respectively. Polychlorinated Dibenzodioxins epidermal growth factor receptor Rattus norvegicus
3 Geldanamycin antagonized the effects of TCDD on EGFR binding activity and TK activity. Polychlorinated Dibenzodioxins epidermal growth factor receptor Rattus norvegicus