Title : Induction of lymphomonocyte activation by HIV-1 glycoprotein gp120. Possible role in AIDS pathogenesis.

Pub. Date : 1996 Oct-Dec

PMID : 9604776






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Gp120 is able to rise intracellular calcium concentration and to induce the formation of inositol triphosphate, can block mitogen- or antigen-driven T cell activation, can induce altered cytokine production by activated PBMC subpopulations, determines impaired cytotoxicity and chemotactic response to antigens, interferes with the activity of antigen presenting cells, enhances or induces apoptosis, stimulates polyclonal B cell activation and induces or up-modulates a number of cytokines, including IL-6. Inositol triphosphate inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens