Title : A phosphatidylcholine phospholipase C inhibitor, D609, blocks interleukin-3 (IL-3)-induced bcl-2 expression but not c-myc expression in human IL-3-dependent cells.

Pub. Date : 1998 May 1

PMID : 9596995






2 Functional Relationships(s)
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1 Using human IL-3-dependent TF-1 cells, we have found that the tyrosine kinase inhibitor genistein blocks both the IL-3 suppression of apoptosis and the expression of the cell survival gene bcl-2. Genistein BCL2 apoptosis regulator Homo sapiens
2 Significantly, genistein inhibited the IL-3 induction of both bcl-2 and c-myc gene. Genistein BCL2 apoptosis regulator Homo sapiens