Title : EGF-dependent and independent programmed cell death pathways in NCI-H596 nonsmall cell lung cancer cells.

Pub. Date : 1998 Apr 28

PMID : 9588219






2 Functional Relationships(s)
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1 In the present study, we evaluated the effect of EGF and genistein, a tyrosine kinase inhibitor, on cell proliferation, EGFR phosphorylation and its downstream signal MAP kinase activation and investigated the involvement of these processes in programmed cell death in a human pulmonary adenosquamous carcinoma cell line, NCI-H596. Genistein epidermal growth factor receptor Homo sapiens
2 Genistein abolished the ability of EGF to induce EGFR phosphorylation, to activate MAP kinase and to increase cell proliferation. Genistein epidermal growth factor receptor Homo sapiens