Pub. Date : 1998 May
PMID : 9585299
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we examined the effects of dantrolene on L-arginine transport and activity of inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide (LPS) and interferon gamma (IFN-gamma) in rat alveolar macrophages. | Dantrolene | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | In addition, dantrolene also attenuated the activity of iNOS in a dose-dependent manner. | Dantrolene | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | We conclude that the mechanisms by which dantrolene attenuated NO synthesis may be associated with the inhibition of availability of L-arginine by reducing the affinity for L-arginine, accompanied by a parallel decrease of the activity of iNOS. | Dantrolene | nitric oxide synthase 2 | Rattus norvegicus |