Title : Tyrosine phosphatase-dependent/tyrosine kinase-independent induction of nuclear factor-kappa B by tumor necrosis factor-alpha: effects on prostaglandin endoperoxide synthase-2 mRNA accumulation.

Pub. Date : 1998 May

PMID : 9580637






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Tyrosine kinase inhibitor, genistein, and tyrosine phosphatase inhibitor, phenylarsine oxide (PAO), blocked TNF-alpha-mediated induction of PGHS-2 mRNA in these cells. oxophenylarsine prostaglandin-endoperoxide synthase 2 Homo sapiens
2 Tyrosine kinase inhibitor, genistein, and tyrosine phosphatase inhibitor, phenylarsine oxide (PAO), blocked TNF-alpha-mediated induction of PGHS-2 mRNA in these cells. oxophenylarsine prostaglandin-endoperoxide synthase 2 Homo sapiens
3 PAO (2.4 microM) completely abolished activation of NF-kappa B and degradation of I kappa B-alpha induced by TNF-alpha at a concentration that blocked PGHS-2 mRNA accumulation. oxophenylarsine prostaglandin-endoperoxide synthase 2 Homo sapiens