Title : Differential regulation of vitamin D responsive elements in normal and transformed keratinocytes.

Pub. Date : 1998 May

PMID : 9579536






3 Functional Relationships(s)
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1 Previous studies from our laboratory showed that phospholipase C-gamma1 (PLC-gamma1) was upregulated transcriptionally by 1,25(OH)2D3 in normal human keratinocytes, and a vitamin D responsive element (VDRE) in its promoter region has been identified. Calcitriol phospholipase C gamma 1 Homo sapiens
2 Previous studies from our laboratory showed that phospholipase C-gamma1 (PLC-gamma1) was upregulated transcriptionally by 1,25(OH)2D3 in normal human keratinocytes, and a vitamin D responsive element (VDRE) in its promoter region has been identified. Calcitriol phospholipase C gamma 1 Homo sapiens
3 The induction of the human PLC-gamma1 VDRE by 1,25(OH)2D3 was synergistic with all-trans retinoic acid in normal human keratinocytes, but none of the constructs was induced by 1,25(OH)2D3 and/or all-trans retinoic acid in SCC4 and SCC12B2 cells. Calcitriol phospholipase C gamma 1 Homo sapiens