Title : Human neutrophils employ myeloperoxidase to convert alpha-amino acids to a battery of reactive aldehydes: a pathway for aldehyde generation at sites of inflammation.

Pub. Date : 1998 May 12

PMID : 9578573






3 Functional Relationships(s)
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1 Human neutrophils employ myeloperoxidase to convert alpha-amino acids to a battery of reactive aldehydes: a pathway for aldehyde generation at sites of inflammation. Amino Acids myeloperoxidase Homo sapiens
2 We now present evidence for the generality of this reaction by demonstrating that neutrophils employ the myeloperoxidase-H2O2-Cl- system to oxidize nearly all of the common alpha-amino acids to yield a family of reactive aldehydes. Amino Acids myeloperoxidase Homo sapiens
3 Stimulated human neutrophils likewise generated aldehydes from all classes of alpha-amino acids by a pathway inhibited by heme poisons and catalase, implicating myeloperoxidase and H2O2 in the cell-mediated reaction. Amino Acids myeloperoxidase Homo sapiens