Title : Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.

Pub. Date : 1998 May 12

PMID : 9576908






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Fhit protein is a diadenosine P1,P3-triphosphate (ApppA) hydrolase whose fungal and animal homologs form a branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins. Histidine fragile histidine triad diadenosine triphosphatase Homo sapiens
2 The form of Fhit bound to two ApppA substrates would present to the cell a dramatically phosphorylated surface, prominently displaying six phosphate groups and two adenosine moieties in place of a deep cavity lined with histidines, arginines, and glutamines. Histidine fragile histidine triad diadenosine triphosphatase Homo sapiens