Title : Tyrosine phosphorylation and association of p130Cas and c-Crk II by ANG II in vascular smooth muscle cells.

Pub. Date : 1998 Apr

PMID : 9575907






7 Functional Relationships(s)
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1 Tyrosine phosphorylation and association of p130Cas and c-Crk II by ANG II in vascular smooth muscle cells. Tyrosine angiotensinogen Homo sapiens
2 In cultured vascular smooth muscle cells (VSMC), angiotensin II (ANG II) stimulated tyrosine phosphorylation of multiple proteins including a 130-kDa protein. Tyrosine angiotensinogen Homo sapiens
3 In cultured vascular smooth muscle cells (VSMC), angiotensin II (ANG II) stimulated tyrosine phosphorylation of multiple proteins including a 130-kDa protein. Tyrosine angiotensinogen Homo sapiens
4 ANG II-stimulated tyrosine phosphorylation of p130Cas was rapid, concentration dependent, and inhibited by the AT1-receptor antagonist CV-11974. Tyrosine angiotensinogen Homo sapiens
5 c-Crk II was also tyrosine phosphorylated in response to ANG II. Tyrosine angiotensinogen Homo sapiens
6 These results indicate that ANG II induces tyrosine phosphorylation of p130Cas and c-Crk II and their specific association, suggesting a potential role of the p130Cas-c-Crk II complex in ANG II signal transduction in VSMC. Tyrosine angiotensinogen Homo sapiens
7 These results indicate that ANG II induces tyrosine phosphorylation of p130Cas and c-Crk II and their specific association, suggesting a potential role of the p130Cas-c-Crk II complex in ANG II signal transduction in VSMC. Tyrosine angiotensinogen Homo sapiens