Title : Extracellular matrix induced by TGFbeta impairs insulin signal transduction in 3T3-L1 preadipose cells.

Pub. Date : 1998 Jun

PMID : 9572482






1 Functional Relationships(s)
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1 Culturing 3T3-L1 preadipose cells on fibronectin, a component of the ECM induced by TGFbeta, also inhibited insulin-dependent IRS-1 tyrosine phosphorylation and adipogenesis, supporting a role for ECM in mediating TGFbeta"s inhibitory effect on insulin signaling. Tyrosine fibronectin 1 Mus musculus