Pub. Date : 1998 Feb 1
PMID : 9570517
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The amino-terminal Src homology 2 domain of phospholipase C gamma 1 is essential for TCR-induced tyrosine phosphorylation of phospholipase C gamma 1. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 2 | The amino-terminal Src homology 2 domain of phospholipase C gamma 1 is essential for TCR-induced tyrosine phosphorylation of phospholipase C gamma 1. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 3 | TCR engagement activates phospholipase C gamma 1 (PLC gamma 1) via a tyrosine phosphorylation-dependent mechanism. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 4 | TCR engagement activates phospholipase C gamma 1 (PLC gamma 1) via a tyrosine phosphorylation-dependent mechanism. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 5 | PLC gamma 1 contains a pair of Src homology 2 (SH2) domains whose function is that of promoting protein interactions by binding phosphorylated tyrosine and adjacent amino acids. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 6 | Mutation of the amino-terminal SH2 domain (SH2(N) domain) resulted in defective tyrosine phosphorylation of PLC gamma 1 in response to TCR/CD3 perturbation. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 7 | In contrast to TCR/CD3 ligation, treatment of cells with pervanadate induced tyrosine phosphorylation of either PLC gamma 1 SH2(N) or SH2(C) domain mutants to a level comparable with that of the wild-type protein, indicating that pervanadate treatment induces an alternate mechanism of PLC gamma 1 phosphorylation. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |