Pub. Date : 1997 Oct
PMID : 9549051
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Other CRH neurons throughout the brain also are involved in coordinating aspects of the stress response, but very little is known about the effect of nicotine on CRH neurons in extrahypothalamic regions that are involved in the autonomic and behavioral responses to stress. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 2 | The current study sought to determine the extent of nicotinic activation of extrahypothalamic CRH neurons, since these neurons may be involved in mediating the central effects of nicotine. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 3 | In all of these areas, nicotine activated CRH neurons in a dose-dependent manner, showing differential sensitivity and efficacy with respect to region. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 4 | CNA CRH neurons were most responsive and were maximally stimulated by the low dose of nicotine (62% of CRH neurons were cFos+, compared to 10-27% of the CRH population in other regions, including the PVN). | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 5 | CNA CRH neurons were most responsive and were maximally stimulated by the low dose of nicotine (62% of CRH neurons were cFos+, compared to 10-27% of the CRH population in other regions, including the PVN). | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 6 | CNA CRH neurons were most responsive and were maximally stimulated by the low dose of nicotine (62% of CRH neurons were cFos+, compared to 10-27% of the CRH population in other regions, including the PVN). | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 7 | These results indicate that the effect(s) of nicotine on the brain may be mediated, in part, by the selective activation of specific extrahypothalamic regions containing CRH neurons that also are involved in autonomic and behavioral responses to stress. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 8 | The large fraction of CRH neurons responding to the low dose of nicotine in the CNA suggests that this limbic region may be particularly important in mediating these CNS effects of nicotine. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 9 | The large fraction of CRH neurons responding to the low dose of nicotine in the CNA suggests that this limbic region may be particularly important in mediating these CNS effects of nicotine. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |