Pub. Date : 1997 Oct
PMID : 9549041
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of GH on IGF-II-induced progesterone accumulation by cultured porcine granulosa cells. | Progesterone | insulin like growth factor 2 | Homo sapiens |
| 2 | IGF-II by itself dose (with peak progesterone production of 498 ng/mg DNA/24 h being observed at 100 ng of IGF-II/mL) and time- (with minimum time requirement of 24-48 h) dependently increased progesterone accumulation (P < 0.01). | Progesterone | insulin like growth factor 2 | Homo sapiens |
| 3 | IGF-II by itself dose (with peak progesterone production of 498 ng/mg DNA/24 h being observed at 100 ng of IGF-II/mL) and time- (with minimum time requirement of 24-48 h) dependently increased progesterone accumulation (P < 0.01). | Progesterone | insulin like growth factor 2 | Homo sapiens |
| 4 | IGF-II by itself dose (with peak progesterone production of 498 ng/mg DNA/24 h being observed at 100 ng of IGF-II/mL) and time- (with minimum time requirement of 24-48 h) dependently increased progesterone accumulation (P < 0.01). | Progesterone | insulin like growth factor 2 | Homo sapiens |
| 5 | However, in the presence of IGF-II, GH proved to be a potent amplifier of IGF-II in progesterone production (P < 0.01) with a minimum GH time requirement of 24-48 h. In contrast, prolactin did not influence IGF-II-induced progesterone accumulation (P > 0.05). | Progesterone | insulin like growth factor 2 | Homo sapiens |
| 6 | However, in the presence of IGF-II, GH proved to be a potent amplifier of IGF-II in progesterone production (P < 0.01) with a minimum GH time requirement of 24-48 h. In contrast, prolactin did not influence IGF-II-induced progesterone accumulation (P > 0.05). | Progesterone | insulin like growth factor 2 | Homo sapiens |
| 7 | However, in the presence of IGF-II, GH proved to be a potent amplifier of IGF-II in progesterone production (P < 0.01) with a minimum GH time requirement of 24-48 h. In contrast, prolactin did not influence IGF-II-induced progesterone accumulation (P > 0.05). | Progesterone | insulin like growth factor 2 | Homo sapiens |
| 8 | However, in the presence of IGF-II, GH proved to be a potent amplifier of IGF-II in progesterone production (P < 0.01) with a minimum GH time requirement of 24-48 h. In contrast, prolactin did not influence IGF-II-induced progesterone accumulation (P > 0.05). | Progesterone | insulin like growth factor 2 | Homo sapiens |
| 9 | An inhibitory study showed that the presence of cycloheximide (3 micrograms/mL) or actinomycin D (1 microgram/mL) blocked both the stimulatory effect of IGF-II on progesterone accumulation and the amplification of GH on IGF-II induced production (P > 0.01), suggesting GH amplification of IGF-II-induced progesterone accumulation is a process involving gene transcription and translation. | Progesterone | insulin like growth factor 2 | Homo sapiens |