Title : An aldose reductase inhibitor prevents glucose-induced increase in transforming growth factor-beta and protein kinase C activity in cultured mesangial cells.

Pub. Date : 1998 Mar

PMID : 9541179






2 Functional Relationships(s)
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1 An aldose reductase inhibitor prevents glucose-induced increase in transforming growth factor-beta and protein kinase C activity in cultured mesangial cells. Glucose aldo-keto reductase family 1 member B Homo sapiens
2 The glucose-induced increase in TGF-beta was prevented by concomitant incubation with epalrestat, an aldose reductase inhibitor (ARI), in a dose-dependent manner at a concentration of more than 10(-6) mol/l. Glucose aldo-keto reductase family 1 member B Homo sapiens