Title : Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury.

Pub. Date : 1998 Apr 14

PMID : 9539776






2 Functional Relationships(s)
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1 However, in the transgenic hearts with overexpression of SOD1 the burst of superoxide generation was almost totally quenched, and this was accompanied by a 2-fold increase in the recovery of contractile function, a 2.2-fold decrease in infarct size, and a greatly improved recovery of high energy phosphates compared with that in nontransgenic controls. Superoxides superoxide dismutase 1, soluble Mus musculus
2 These results demonstrate that superoxide is an important mediator of postischemic injury and that increasing intracellular SOD1 dramatically protects the heart from this injury. Superoxides superoxide dismutase 1, soluble Mus musculus