Title : Platelets enhance contractility in perfused rat mesenteric arteries: involvement of endothelin-1.

Pub. Date : 1997 Dec 11

PMID : 9537817






2 Functional Relationships(s)
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1 Suppressor doses of endothelin-1 (3 x 10(-10) M) or sarafotoxin S6c (S6c) (3 x 10(-10) M) potentiated significantly the norepinephrine-induced vasoconstriction, in the same preparation. Norepinephrine endothelin 1 Rattus norvegicus
2 These results suggest that platelet-derived TGF-beta1 stimulates the vascular production of endothelin-1 and thereby enhances vasoconstrictor responses to norepinephrine. Norepinephrine endothelin 1 Rattus norvegicus