Title : Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.

Pub. Date : 1998 Apr

PMID : 9531525






1 Functional Relationships(s)
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1 Ketoconazole (5 microM), a selective CYP3A inhibitor, produced up to 75% inhibition, whereas other CYP-specific inhibitors, i.e. quinidine (CYP2D6), 7,8-benzoflavone (CYP1A2), and sulfaphenazole (CYP2C9), showed no significant effects. Ketoconazole cytochrome P450 family 2 subfamily C member 9 Homo sapiens