Title : Insulin-like growth factor-I promotes multidrug resistance in MCLM colon cancer cells.

Pub. Date : 1998 May

PMID : 9525472






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Results demonstrated that 1) IGF-I significantly inhibited the cell death and apoptosis of MCLM cells treated with Act-D, LOV, or DOX; 2) IGF-I increased mRNA expression for mdr-1, c-H-ras, and MnSOD; 3) the p-glycoproteins in cells treated with IGF-I or stably transfected with c-H-ras were elevated when compared with control. Doxorubicin ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus