Title : Suppression of astroglial nitric oxide synthase expression by norepinephrine results from decreased NOS-2 promoter activity.

Pub. Date : 1998 Apr

PMID : 9523565






1 Functional Relationships(s)
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1 These results suggest that the suppressive effects of NE are due to modification of transcription factor activity in a region located between -1,588 and -85 of the NOS-2 promoter and may help explain observations that in some cells cyclic AMP can potentiate, rather than suppress, NOS-2 expression. Cyclic AMP nitric oxide synthase 2 Rattus norvegicus