Title : Regulation of cardiac myocyte contractile function by inducible nitric oxide synthase (iNOS): mechanisms of contractile depression by nitric oxide.

Pub. Date : 1998 Feb

PMID : 9515007






2 Functional Relationships(s)
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1 Pre-incubation of the cells in isobutylmethylxanthine (IBMX), a phosphodiesterase inhibitor, also partly reversed the attenuation of cAMP increase with 2 nM Iso in cells expressing iNOS. Cyclic AMP nitric oxide synthase 2 Rattus norvegicus
2 We conclude that NO endogenously produced by iNOS decreases the intracellular levels of cAMP in response to beta-adrenergic stimulation in isolated cardiac myocytes, in part through a cGMP-mediated mechanism. Cyclic AMP nitric oxide synthase 2 Rattus norvegicus