Title : Striatal increase of neurotrophic factors as a mechanism of nicotine protection in experimental parkinsonism.

Pub. Date : 1997

PMID : 9503263






3 Functional Relationships(s)
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1 In parallel experiments, we found that (-)nicotine induces the basic fibroblast growth factor (FGF-2) and the brain-derived neurotrophic factor (BDNF) in rat striatum. Nicotine brain-derived neurotrophic factor Rattus norvegicus
2 In parallel experiments, we found that (-)nicotine induces the basic fibroblast growth factor (FGF-2) and the brain-derived neurotrophic factor (BDNF) in rat striatum. Nicotine brain-derived neurotrophic factor Rattus norvegicus
3 As FGF-2 and BDNF have been reported to be neuroprotective for dopaminergic cells, our data indicate that the increase in neurotrophic factors is a possible mechanism by which (-)nicotine protects from experimental parkinsonisms. Nicotine brain-derived neurotrophic factor Rattus norvegicus