Title : Molecular modeling of ligand and mutation sites of the type A domains of human von Willebrand factor and their relevance to von Willebrand's disease.

Pub. Date : 1998 Mar 15

PMID : 9490688






2 Functional Relationships(s)
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Protein Name
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1 The A1, A2, and A3 domains in vWF mediate binding to glycoprotein Ib, ristocetin, botrocetin, collagen, sulphatides, and heparin and provide a protease cleavage site. Heparin von Willebrand factor Homo sapiens
2 Because heparin binding inhibits the interaction with GpIb, this provides an explanation of vWF upregulation. Heparin von Willebrand factor Homo sapiens