Pub. Date : 1998 Feb 1
PMID : 9490065
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In liver microsomes, the demethylation of imipramine was essentially due to CYP1A2 and to a smaller extent to CYP3A. | Imipramine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In fetuses and early neonates, CYP3A proteins were responsible for the low demethylation of imipramine (3-4% of the adult activity) before the onset of CYP1A2 and the subsequent rise of activity. | Imipramine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |