Title : Chronic ethanol treatment decreases [3H]epibatidine and [3H]nicotine binding and differentially regulates mRNA levels of nicotinic acetylcholine receptor subunits expressed in M10 and SH-SY5Y neuroblastoma cells.

Pub. Date : 1998 Mar

PMID : 9489734






1 Functional Relationships(s)
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1 Changes in the levels of nAChR protein and mRNA may have adaptive significance and be involved in the development of dependence, tolerance, and addiction to chronic ethanol and nicotine exposure. Nicotine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens