Title : Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux.

Pub. Date : 1998 Feb 17

PMID : 9465036






2 Functional Relationships(s)
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1 Although Bcl-2 had no effect on the respiration rate of isolated mitochondria, it prevented both Deltapsi loss and the permeability transition (PT) induced by various reagents, including Ca2+, H2O2, and tert-butyl hydroperoxide. tert-Butylhydroperoxide BCL2 apoptosis regulator Homo sapiens
2 Furthermore, Bcl-2 enhanced H+ efflux but not K+ flux after treatment of mitochondria with Ca2+ or tert-butyl hydroperoxide. tert-Butylhydroperoxide BCL2 apoptosis regulator Homo sapiens