Title : Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.

Pub. Date : 1998 Feb 15

PMID : 9461503






4 Functional Relationships(s)
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1 Some animals also received 3-methylcholanthrene (MC) to induce hepatic CYP1A2. Methylcholanthrene cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus
2 Treatment with MC increased hepatic CYP1A1 in both mouse lines and hepatic CYP1A2 only in the Cyp1a2(+/+) line, as determined by Western immunoblotting. Methylcholanthrene cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus
3 Treatment with MC increased hepatic CYP1A1 in both mouse lines and hepatic CYP1A2 only in the Cyp1a2(+/+) line, as determined by Western immunoblotting. Methylcholanthrene cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus
4 MC increased hepatic ethoxy- and methoxy-resorufin O-dealkylase activities in both mouse lines, but increased uroporphyrinogen oxidation activity in the Cyp1a2(+/+) wild-type mice only. Methylcholanthrene cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus