Title : Suppression of uterine insulin-like growth factor binding protein 5 by estrogen is mediated in part by insulin-like growth factor I.

Pub. Date : 1998 Feb

PMID : 9458371






1 Functional Relationships(s)
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1 In vitro studies using primary uterine cells reveal that IGF-I increases thymidine incorporation and inhibits IGFBP-5 gene expression, whereas estradiol has no effect suggesting that in vivo estradiol-induced IGFBP-5 suppression is mediated through increased IGF-I production. Thymidine insulin-like growth factor 1 Rattus norvegicus