Title : Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer.

Pub. Date : 1998 Feb 6

PMID : 9452426






3 Functional Relationships(s)
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Protein Name
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1 In the biosynthesis of steroid hormones, P450c17 is the single enzyme that catalyzes both the 17alpha-hydroxylation of 21-carbon steroids and the 17,20-lyase activity that cleaves the C17-C20 bond to produce C19 sex steroids. Steroids cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 In the biosynthesis of steroid hormones, P450c17 is the single enzyme that catalyzes both the 17alpha-hydroxylation of 21-carbon steroids and the 17,20-lyase activity that cleaves the C17-C20 bond to produce C19 sex steroids. Steroids cytochrome P450 family 17 subfamily A member 1 Homo sapiens
3 Yeast expressing only P450c17 have 17alpha-hydroxylase and trace 17,20-lyase activities toward both Delta4 and Delta5 steroids. Steroids cytochrome P450 family 17 subfamily A member 1 Homo sapiens