Title : Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes.

Pub. Date : 1998 Jan 30

PMID : 9446561






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Inhibition of ceramide and LPS-mediated induction of iNOS by antioxidant inhibitors of NF-kappaB (N-acetylcysteine and pyrrolidine dithiocarbamate) suggest that the stimulatory effect of ceramide on the induction of iNOS is due to the stimulation of NF-kappaB activation and that cellular redox plays a role in the activation of NF-kappaB and induction of iNOS. pyrrolidine dithiocarbamic acid nitric oxide synthase 2 Rattus norvegicus