Title : Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol.

Pub. Date : 1997 Dec

PMID : 9431831






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 HAL inhibited dextromethorphan O-demethylase (CYP2D6) with IC50 values between 2.7 and 8.5 microM, but not (IC50 > 100 microM) dextromethorphan N-demethylase (CYP3A4), phenacetin O-deethylase (CYP1A2) or tolbutamide hydroxylase (CYP2C9). Haloperidol cytochrome P450 family 2 subfamily C member 9 Homo sapiens