Pub. Date : 1997 Nov 15
PMID : 9426159
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 11 beta-hydroxysteroid dehydrogenase-2 is a high affinity corticosterone-binding protein. | Corticosterone | hydroxysteroid 11-beta dehydrogenase 2 | Homo sapiens |
| 2 | Based on similarities in steroid specificity and kinetic parameters, we hypothesized that these corticosterone binding sites belong to the type 2 isoform of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD2). | Corticosterone | hydroxysteroid 11-beta dehydrogenase 2 | Homo sapiens |
| 3 | Based on similarities in steroid specificity and kinetic parameters, we hypothesized that these corticosterone binding sites belong to the type 2 isoform of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD2). | Corticosterone | hydroxysteroid 11-beta dehydrogenase 2 | Homo sapiens |
| 4 | The goal of this study was to express the recombinant rabbit 11 beta-HSD2 in mammalian cells and test if such cells acquire both NAD-dependent 11 beta-HSD2 activity as well as high affinity corticosterone binding sites. | Corticosterone | hydroxysteroid 11-beta dehydrogenase 2 | Homo sapiens |
| 5 | The steroid specificity of the binding sites, as determined by competing [3H]corticosterone with unlabeled steroids, is identical to that of 11 beta-HSD2: corticosterone >> 11-hydroxyprogesterone > carbenoxolone > 11 dehydrocorticosterone > cortisol > progesterone approximately DOC >>> DEX > RU 28362 - aldosterone. | Corticosterone | hydroxysteroid 11-beta dehydrogenase 2 | Homo sapiens |
| 6 | These results strongly suggest that the previously described high affinity corticosterone binding sites are 11 beta-HSD2. | Corticosterone | hydroxysteroid 11-beta dehydrogenase 2 | Homo sapiens |