Protein Name hydroxysteroid 11-beta dehydrogenase 2
Organism Homo sapiens
Gene ID 3291
Gene Symbol


UniProt P80365 (DHI2_HUMAN)
Relationships Total Number of functionally related compound(s) : 300
Total Number of Articles : 505

hydroxysteroid 11-beta dehydrogenase 2

Gene Summary

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]

  • 11-beta-hydroxysteroid dehydrogenase type 2
  • -HSD11 type II
  • 11-DH2
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