Pub. Date : 1997 Dec
PMID : 9415707
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identification of benzo[a]pyrene-inducible cis-acting elements within c-Ha-ras transcriptional regulatory sequences. | Benzo(a)pyrene | Harvey rat sarcoma virus oncogene | Mus musculus |
| 2 | Previous studies in this laboratory have demonstrated that transcriptional deregulation of c-Ha-ras expression is associated with the induction and maintenance of proliferative vascular smooth muscle cell (SMC) phenotypes by benzo[a]pyrene (BaP). | Benzo(a)pyrene | Harvey rat sarcoma virus oncogene | Mus musculus |
| 3 | Previous studies in this laboratory have demonstrated that transcriptional deregulation of c-Ha-ras expression is associated with the induction and maintenance of proliferative vascular smooth muscle cell (SMC) phenotypes by benzo[a]pyrene (BaP). | Benzo(a)pyrene | Harvey rat sarcoma virus oncogene | Mus musculus |
| 4 | We examined previously undescribed cis-acting elements within the proximal 5" regulatory region of c-Ha-ras (-550 to +220) for their ability to influence BaP-induced transcription in murine SMCs. | Benzo(a)pyrene | Harvey rat sarcoma virus oncogene | Mus musculus |
| 5 | The use of monoclonal antibodies to the aryl hydrocarbon receptor transcription factor in competition electrophoretic mobility shift assays indicated this protein is specifically induced by BaP to interact at the AHRE within the c-Ha-ras 5" regulatory region. | Benzo(a)pyrene | Harvey rat sarcoma virus oncogene | Mus musculus |
| 6 | These data indicate that c-Ha-ras gene expression is modulated by BaP via a complex mechanism that likely involves interactions among multiple regulatory elements. | Benzo(a)pyrene | Harvey rat sarcoma virus oncogene | Mus musculus |