Title : BDNF attenuates functional and structural disorders in nerves of galactose-fed rats.

Pub. Date : 1997 Dec

PMID : 9413278






3 Functional Relationships(s)
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1 Galactose intoxication of rats was used to disrupt metabolism of Schwann cells and skeletal muscle, two sites that contain the polyol-forming enzyme aldose reductase (AR). Galactose aldo-keto reductase family 1 member B1 Rattus norvegicus
2 Galactose intoxication of rats was used to disrupt metabolism of Schwann cells and skeletal muscle, two sites that contain the polyol-forming enzyme aldose reductase (AR). Galactose aldo-keto reductase family 1 member B1 Rattus norvegicus
3 To investigate the possibility that galactose metabolism by AR influences axonal function and structure by altering production of neurotrophic factors, the impact of galactose intoxication on nerve and muscle BDNF levels and the effects of exogenous BDNF treatment on galactose neuropathy were examined using biochemical, electrophysiologic and morphometric techniques. Galactose aldo-keto reductase family 1 member B1 Rattus norvegicus