Pub. Date : 1997 Nov
PMID : 9409294
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes. | cafestol | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 2 | Dose-dependent decreases of bile acid mass production and cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase activity were found, showing a maximal reduction of -91%, -79%, and -49% respectively, at a concentration of 20 micrograms/mL cafestol. | cafestol | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 3 | The mixture of cafestol/kahweol/isokahweol was less potent in suppression of bile acid synthesis and cholesterol 7 alpha-hydroxylase. | cafestol | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 4 | We conclude that cafestol suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and of, to a lesser extent, sterol 27-hydroxylase in cultured rat hepatocytes, whereas kahweol and isokahweol are less active. | cafestol | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |