Title : Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes.

Pub. Date : 1997 Nov 20

PMID : 9399644






2 Functional Relationships(s)
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1 We now show that cyclin E/cdk2 phosphorylates p27 at a carboxy-terminal threonine residue (T187) in vitro; mutation of this residue to valine stabilises cyclin E/cdk2 complexes. Threonine cyclin dependent kinase 2 Homo sapiens
2 After induction of Myc, p27 phosphorylated at threonine 187 transiently accumulates in a non cdk2 bound form. Threonine cyclin dependent kinase 2 Homo sapiens