Title : Comparison of key steps in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in rodents.

Pub. Date : 1997 Nov

PMID : 9396088






2 Functional Relationships(s)
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1 Firstly, we compared the neurotoxicity of MPTP, mediated by monoamine oxidase (MAO)-B, to that of 1-methyl-4-(2"-methylphenyl)-1,2,3,6-tetrahydropyridine (2"-CH3-MPTP), an analogue oxidized by MAO-A and MAO-B. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Rattus norvegicus
2 Firstly, we compared the neurotoxicity of MPTP, mediated by monoamine oxidase (MAO)-B, to that of 1-methyl-4-(2"-methylphenyl)-1,2,3,6-tetrahydropyridine (2"-CH3-MPTP), an analogue oxidized by MAO-A and MAO-B. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Rattus norvegicus